PCI-24781

PCI-24781 (Abexinostat) is a broad-spectrum phenyl hydroxamic acid HDAC inhibitor currently being evaluated in phase I clinical trials in patients with neoplastic disease. The substance is a specific inhibitor of multiple HDAC isoforms (HDAC2, HDAC3/SMRT, HDAC6, HDAC8, HDAC10) that potently inhibits tumor growth in vivo with acceptable toxicity.

Synonyms: PCI-24781; Abexinostat; CRA-02478; CRA024781; CRA-024781
Technical Data: Molecular Weight - 397.43; Molecular formula - C21H23N3O5; CAS No - 783355-60-2

Ordering Information: Product Number - EC-000.2348
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References:
1. Adimoolam S, Sirisawad M, Chen J, et al. HDAC inhibitor PCI-24781 decreases RAD51 expression and inhibits homologous recombination. Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19482-7.
2. Joseph J. Buggy, Z. Alexander Cao, et al. CRA-024781: a novel synthetic inhibitor of histone deacetylase enzymes with antitumor activity in vitro and in vivo. Mol Cancer Ther May 2006 5; 1309.

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Related service: collection of Histone Deacetylase Inhibitors.