BML281

BML-281 is a potent and selective HDAC3 and HDAC6 inhibitor. Potent inhibitor of the proliferation of a variety of pancreatic cancer cell lines (IC50 in the 0.1-0.6 µM range). This compound, for example, is active against both the Mia Paca-2 and Panc04.03 cell lines at the 100 nM level and at the 200-300 nM level against HupT3.

BML-281

Synonyms: tert-butyl 4-(3-(7-(hydroxyamino)-7-oxoheptylcarbamoyl)isoxazol-5-yl)phenylcarbamate
Technical Data: Molecular Weight - 446.51; Molecular formula - C22H30N4O6; CAS No - 1045792-66-2

Ordering Information: Product Number - EC-000.2466
Price and Availability: Inquire
This product is also available to buy in bulk quantities.

References:
1. Use of the Nitrile Oxide Cycloaddition (NOC) Reaction for Molecular Probe Generation: A New Class of Enzyme Selective Histone Deacetylase Inhibitors (HDACIs) Showing Picomolar Activity at HDAC6 : A.P. Kozikowski, et al.; J. Med. Chem. 51, 4370 (2008).

Related Products: Suberoylanilide Hydroxamic Acid; MS-275 (Entinostat); CI-994 (Tacedinaline); BML-210; M344; MGCD0103 (Mocetinostat); PXD101 (Belinostat); LBH-589 (Panobinostat); Tubastatin A; Scriptaid; NSC 3852; NCH 51; HNHA; CBHA; Salermide; Pimelic Diphenylamide; ITF2357 (Givinostat); PCI-24781; APHA Compound 8; Droxinostat; SB939.

Related service: collection of Histone Deacetylase Inhibitors.