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BML-210

BML-210

BML-210 is a small molecule inhibitor of HDAC with an IC50 value of 30 µM when tested in HeLa cell nuclear extracts using 200 µM acetylated fluorometric substrate. This compound also inhibits the deacetylation of the transcription factor FOXO3 by mammalian SIRT1 in cells oxidatively stressed by hydrogen peroxide.

Synonyms: BML 210; N-(2-aminophenyl)-N'-phenyl-octanediamide
Technical Data: Molecular Weight - 339.44; Molecular formula - C20H25N3O2; CAS No - 537034-17-6

Ordering Information: Product Number - EC-000.2274; Price and Availability: Inquire This product is also available to buy in bulk quantities.

Related Products: Suberoylanilide Hydroxamic Acid; MS-275 (Entinostat); CI-994 (Tacedinaline); M344; MGCD0103 (Mocetinostat); PXD101 (Belinostat); LBH-589 (Panobinostat); Tubastatin A; Scriptaid; NSC 3852; NCH 51; HNHA; BML-281; CBHA; Salermide; Pimelic Diphenylamide; ITF2357 (Givinostat); PCI-24781; APHA Compound 8; Droxinostat; SB939.

References:
1. Yoshida, M., et al. Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A. J Biol Chem 265(28) 17174-17179 (1990).
2. Savickiene J, et al. The novel histone deacetylase inhibitor BML-210 exerts growth inhibitory, proapoptotic and differentiation stimulating effects on the human leukemia cell lines. Eur J Pharmacol. 2006 Nov 7;549(1-3):9-18.
3. Brunet, A., et al. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303 2011-2015 (2004).


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