BML-210
BML-210 is a small molecule inhibitor of HDAC with an IC50 value of 30 µM when tested in HeLa cell nuclear extracts using 200 µM acetylated fluorometric substrate. This compound also inhibits the deacetylation of the transcription factor FOXO3 by mammalian SIRT1 in cells oxidatively stressed by hydrogen peroxide.
Synonyms: BML 210; N-(2-aminophenyl)-N'-phenyl-octanediamide
Technical Data: Molecular Weight - 339.44; Molecular formula - C20H25N3O2; CAS No - 537034-17-6
Ordering Information: Product Number - EC-000.2274
Price and Availability: Inquire
This product is also available to buy in bulk quantities.
Special offer
We are pleased to offer you set of eight HDAC inhibitors* at the best current market price:
$600/8 inhibitors* x 10 mg
$1100/8 inhibitors* x 50 mg
$1450/8 inhibitors* x 100 mg
Shipping and handling costs: $150
Delivery time: 5-10 days by courier from stock.
This special sale is for limited time only
* - Suberoylanilide Hydroxamic Acid (SAHA);
Entinostat (MS-275);
Tacedinaline (CI-994);
BML-210;
M344;
Mocetinostat (MGCD0103);
PXD101;
LBH-589.
References:
1. Yoshida, M., et al. Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A. J Biol Chem 265(28) 17174-17179 (1990).
2. Savickiene J, et al. The novel histone deacetylase inhibitor BML-210 exerts growth inhibitory, proapoptotic and differentiation stimulating effects on the human leukemia cell lines. Eur J Pharmacol. 2006 Nov 7;549(1-3):9-18.
3. Brunet, A., et al. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303 2011-2015 (2004).
Related Products: Suberoylanilide Hydroxamic Acid; MS-275 (Entinostat); CI-994 (Tacedinaline); M344; MGCD0103 (Mocetinostat); PXD101 (Belinostat); LBH-589 (Panobinostat); Tubastatin A; Scriptaid; NSC 3852; NCH 51; HNHA; BML-281; CBHA; Salermide; Pimelic Diphenylamide; ITF2357 (Givinostat); PCI-24781; APHA Compound 8; Droxinostat; SB939.
Related service: collection of Histone Deacetylase Inhibitors.