ITF2357 is an inhibitor of HDAC activity (class I and class II HDAC) but also is an anti-inflammatory agent in vitro and in vivo. Enzymatically, ITF2357 inhibits different histone deacetylases from maize, and biochemical analysis revealed that, similar to SAHA, ITF2357 hyperacetylates histones in human PBMCs.
Synonyms: ITF-2357; Gavinostat; ITF2357
Technical Data: Molecular Weight - 421.50; Molecular formula - C24H27N3O4; CAS No - 732302-99-7
Ordering Information: Product Number - EC-000.2471
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References:
1. Flavio Leoni, Gianluca Fossati, et al. The Histone Deacetylase Inhibitor ITF2357 Reduces Production of Pro-Inflammatory Cytokines In Vitro and Systemic Inflammation In Vivo. Mol Med. 2005 Jan–Dec; 11(1-12): 1–15.
2. Shein NA, Grigoriadis N, et al. Histone deacetylase inhibitor ITF2357 is neuroprotective, improves functional recovery, and induces glial apoptosis following experimental traumatic brain injury. FASEB J. 2009 Dec;23(12):4266-75.
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Related service: collection of Histone Deacetylase Inhibitors.