Home Site map Contacts
 

Givinostat

Givinostat, ITF-2357, Gavinostat, ITF2357

ITF2357 is an inhibitor of HDAC activity (class I and class II HDAC) but also is an anti-inflammatory agent in vitro and in vivo. Enzymatically, ITF2357 inhibits different histone deacetylases from maize, and biochemical analysis revealed that, similar to SAHA, ITF2357 hyperacetylates histones in human PBMCs.

Synonyms: ITF-2357; Gavinostat; ITF2357
Technical Data: Molecular Weight - 421.50; Molecular formula - C24H27N3O4; CAS No - 732302-99-7

Ordering Information: Product Number - EC-000.2471; Price and Availability: Inquire This product is also available to buy in bulk quantities.

Related Products: Suberoylanilide Hydroxamic Acid; MS-275 (Entinostat); CI-994 (Tacedinaline); BML-210; M344; MGCD0103 (Mocetinostat); PXD101 (Belinostat); LBH-589 (Panobinostat); Tubastatin A; Scriptaid; NSC 3852; NCH 51; HNHA; BML-281; CBHA; Salermide; Pimelic Diphenylamide; PCI-24781; APHA Compound 8; Droxinostat; SB939.

References:
1. Flavio Leoni, Gianluca Fossati, et al. The Histone Deacetylase Inhibitor ITF2357 Reduces Production of Pro-Inflammatory Cytokines In Vitro and Systemic Inflammation In Vivo. Mol Med. 2005 Jan–Dec; 11(1-12): 1–15.
2. Shein NA, Grigoriadis N, et al. Histone deacetylase inhibitor ITF2357 is neuroprotective, improves functional recovery, and induces glial apoptosis following experimental traumatic brain injury. FASEB J. 2009 Dec;23(12):4266-75.


Home  |  About Company  |  Contract Synthesis  |  Cheminformatics Services  |  Info for Chemists  |  Contacts  |  FAQ  |  Site Map

© 2004-2016 Exclusive Chemistry Ltd. All rights reserved.