NSC3852

NSC3852 has cell differentiation and antiproliferative activity in human breast cancer cells in tissue culture and antitumor activity in mice bearing P388 and L1210 leukemic cells. NSC3852 inhibited histone deacetylase (HDAC) activity in vitro and caused DNA damage and apoptosis in MCF-7 cells, consistent with their differentiation and antiproliferative activities. This compound could inhibit HDAC activity by 80% at 190 µM, it also inhibited an unrelated protease enzyme assay by 40%, indicating some nonspecific activity at this concentration.

Synonyms: 5-nitroso-8-quinolinol; 5-nitrosoquinolin-8-ol; NSC 3852
Technical Data: Molecular Weight - 174.16; Molecular formula - C9H6N2O2; CAS No - 3565-26-2

Ordering Information: Product Number - EC-000.2461; Price and Availability: Inquire This product is also available to buy in bulk quantities.

Related Products: Suberoylanilide Hydroxamic Acid; MS-275 (Entinostat); CI-994 (Tacedinaline); BML-210; M344; MGCD0103 (Mocetinostat); PXD101 (Belinostat); LBH-589 (Panobinostat); Tubastatin A; Scriptaid; NCH 51; HNHA; BML-281; CBHA; Salermide; Pimelic Diphenylamide; ITF2357 (Givinostat); PCI-24781; APHA Compound 8; Droxinostat; SB939.

References:
1. Martirosyan A, Leonard S, Shi X., et al. Actions of a histone deacetylase inhibitor NSC3852 (5-nitroso-8-quinolinol) link reactive oxygen species to cell differentiation and apoptosis in MCF-7 human mammary tumor cells. J Pharmacol Exp Ther. 2006 May; 317(2):546-52.
2. Ronald L. Johnson, Wenwei Huang, et al. A quantitative high-throughput screen identifies potential epigenetic modulators of gene expression. Analytical Biochemistry, Volume 375, Issue 2, 15 April 2008, Pages 237-248. DOI: 10.1016/j.ab.2007.12.028.