APHA Compound 8

APHA Compound 8 is a potent novel hydroxamate HDAC inhibitor, is in the same structural class as SAHA, an investigational drug standard currently in clinical trial. The IC50 for mouse HDAC1 is 0.5 µM. In a separate study, significant inhibition was found in the proliferation of MEL cells at 24 µM and differentiation, assayed as the accumulation of hemoglobin, at 5 µM.

Synonyms: 3-(1-Methyl-4-phenylacetyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide
Technical Data: Molecular Weight - 284.32; Molecular formula - C16H16N2O3; CAS No - 676599-90-9

Ordering Information: Product Number - EC-000.2464; Price and Availability: Inquire This product is also available to buy in bulk quantities.

Related Products: Suberoylanilide Hydroxamic Acid; MS-275 (Entinostat); CI-994 (Tacedinaline); BML-210; M344; MGCD0103 (Mocetinostat); PXD101 (Belinostat); LBH-589 (Panobinostat); Tubastatin A; Scriptaid; NSC 3852; NCH 51; HNHA; BML-281; CBHA; Salermide; Pimelic Diphenylamide; ITF2357 (Givinostat); PCI-24781; Droxinostat; SB939.

References:
1. Mai Antonello, Massa Silvio, Ragno Rino., et al. 3-(4-Aroyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-alkylamides as a New Class of Synthetic Histone Deacetylase Inhibitors. 1. Design, Synthesis, Biological Evaluation, and Binding Mode Studies Performed through Three Different Docking Procedures. J. Med. Chem., 2003, 46 (4), pp 512–524.