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APHA Compound 8


APHA Compound 8 is a potent novel hydroxamate HDAC inhibitor, is in the same structural class as SAHA, an investigational drug standard currently in clinical trial. The IC50 for mouse HDAC1 is 0.5 µM. In a separate study, significant inhibition was found in the proliferation of MEL cells at 24 µM and differentiation, assayed as the accumulation of hemoglobin, at 5 µM.

Synonyms: 3-(1-Methyl-4-phenylacetyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide
Technical Data: Molecular Weight - 284.32; Molecular formula - C16H16N2O3; CAS No - 676599-90-9

Ordering Information: Product Number - EC-000.2464; Price and Availability: Inquire This product is also available to buy in bulk quantities.

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1. Mai Antonello, Massa Silvio, Ragno Rino., et al. 3-(4-Aroyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-alkylamides as a New Class of Synthetic Histone Deacetylase Inhibitors. 1. Design, Synthesis, Biological Evaluation, and Binding Mode Studies Performed through Three Different Docking Procedures. J. Med. Chem., 2003, 46 (4), pp 512524.

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