NCH 51

NCH-51 is a novel non-hydroxamic acid histone deacetylase (HDAC) inhibitor that could inhibit the cell growth of a variety of lymphoid malignant cells through apoptosis induction, more effectively than SAHA. Activation of caspase-3, -8 and -9, but not -7 was detected after the treatment with NCH-51. Gene expression profiles showed that NCH-51 and SAHA similarly upregulated p21 and downregulated anti-apoptotic molecules including survivin, bcl-w and c-FLIP.

Synonyms: NCH51; PTACH; S-7-oxo-7-(4-phenylthiazol-2-ylamino)heptyl 2-methylpropanethioate
Technical Data: Molecular Weight - 390.57; Molecular formula - C20H26N2O2S2; CAS No - 848354-66-5

Ordering Information: Product Number - EC-000.2462; Price and Availability: Inquire This product is also available to buy in bulk quantities.

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References:
1. Sanda T; Okamoto T; Uchida Y., et al. Proteome analyses of the growth inhibitory effects of NCH-51, a novel histone deacetylase inhibitor, on lymphoid malignant cells. Leukemia 2007;21:2344–53.